For every human being, growth hormone plays an essential role in regulating the body’s organ function, bone density, and tissue growth. However, once adults reach their 40s, growth hormone production begins to decline, leading to age-related symptoms such as decreased muscle mass and brittle bone mass. And as growth hormone deficiency continues, our bodies become vulnerable to more serious health issues, such as chronic pain, bone inflammation, and an increased risk for heart disease. But although age is a natural process of life that can’t be stopped, it can be slowed down if low growth hormone levels are restored to optimal standards.
Peptide therapy is a form of hormone replacement therapy that can help replenish declining GH levels. Currently seen as one of the most effective anti-aging treatments, peptide therapy utilizes synthetic peptides to mimic and stimulate increased GH production to treat growth hormone deficiency. Growth hormone-releasing peptides (GHRP) such as Sermorelin and Ipamorelin can be used to restore growth hormone and, at times, can even pair with other types of peptides as an effective testosterone replacement medicine to optimize increased growth hormone production. One of the most effective peptides that physicians have found to work best with Ipamorelin in treating GH deficiency and age-related health issues is the peptide CJC-1295.
CJC 1295 Ipamorelin is a combination of 2 peptides. It is a Growth Hormone releasing hormone that stimulates one side of the pituitary gland. It does this in order to produce growth hormone. Ipamorelin mimics the ghrelin and binds to the ghrelin receptor in the pituitary gland in the brain. Thus, it also acts on the pituitary gland in order to produce growth hormone. These two peptides combine to act together in order to increase HGH (human growth hormone) produced in the body. The CJC 1295 Ipamorelin combo is able to achieve this by acting in two different families of receptors.
What Is CJC-1295?
The CJC-1295 is a synthetic growth hormone-releasing hormone (GHRH) peptide with 30 amino acids that stimulate increased growth hormone secretion and insulin growth factor (IGF-1). By stimulating one side of the pituitary gland to produce more GH, CJC-1295 can help increase muscle mass and strength. So have performance-enhancing effects that appeal to athletes. Originally created to treat diseases, CJC-1295 has shown to exhibit anti-aging properties, making it a very effective regenerative medicine for other medical conditions besides GH deficiency.
CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.
What Is Ipamorelin?
is a hormone secretagogue, meaning it helps excrete hormones into the bloodstream while simulating the pituitary gland to produce them. It serves other functions as well. Ipamorelin is associated with improved cognitive skills, memory, pain relief, and internal body temperature regulation along with growth and muscle development.
What is the different of CJS-1295 with DAC and CJC-1295 without DAC
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).
The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases its half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.
The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.
What Are the Benefits of CJC-1295?
Experiencing several benefits after using CJC-1295 for treatment, which include:
- Increased Bone Density: As we get older, our bones get brittle, that is why injuries are more common.
- Increase in muscle mass
- Strengthens the cardiovascular system: More muscle mass = higher metabolism = less body fat
- The ability to burn fat: With an increase in muscle mass allows the body’s resting metabolic rate is boosted leading to more calories burned throughout the day.
- Increased Sex drive: Sex his huge. Not being able to function properly sexually can really take a toll on your mental well-being.
- Improved Recovery and Repair from Injuries: Being on a proper bio-identical hormone replacement therapy program leads to an overall improved state of well-being. This adheres to recovery time (soreness) and acute musculoskeletal injuries.
- Strengthens Immune System: It is a tremendous benefit when you are trying to attain optimal health and that is achieved by having a strong immune system
Improves cognition and memory function-It is an improved overall benefit to the body, this includes focus and feeling mental clarity and sharpness throughout the day.
Improves Insulin Sensitivity-CJC-1295 and Ipamorelin improves insulin sensitivity thus reducing the body’s triglycerides. High blood sugars are reduced which helps burning more body fat.
CJC-1295 can also improve other age-related issues such as cognitive memory function and mental clarity. The CJC-1295 peptide also provides fat-burning properties by reducing triglyceride production, which leads to high blood sugar. By lowering high blood sugar levels and changing body composition, CJC-1295 can help the patients burn more calories and improve fat loss. Thanks to its ability to increase growth hormone production and boost testosterone levels, CJC-1295 can also help improve sexual issues such as erectile dysfunction and premature ejaculation.
What are the side effects of CJC-1295 / Ipamorelin?
One of the biggest reasons why CJC-1295 is being embraced by so many in their anti-aging fight is because of the relatively low rate of side effects. Most people tolerate CJC-1295 quite well, and side effects are generally mild if present at all. The most frequent side effect was injection site reaction – usually skin complaints or mild pain at the site of injection.
As with most medications, CJC 1295 can cause certain side effects when introduced to the body. The most common side effects of CJC-1295 include:
- Sensitivity and Anxiety
- Irritability
- soreness, or pain at the injection site,
- Flu-like symptoms,
- Headache,
- Dizziness,
- Nausea,
- Drowsiness,
- Flushing,
- Hives or other skin reactions,
- Hyperactivity,
- Difficulty swallowing
Patients undergoing long-term CJC-1295 treatment may also experience pain and swelling after repeated shots to the same injection site. In rare cases, some patients have experienced mild hypertension and water retention. Before starting treatment, you should discuss the side effects of using CJC-1295 peptide therapy with your physician to determine if the compound is suitable for you to use as a long-term treatment.
How does CJC 1295 work?
Ipamorelin and CJC 1295 are often used together to stimulate muscle development. The combination works by increasing the blood level of hormones associated with growth. It can increase muscle mass and strength, decrease body fat, improve injury recovery time, and even improve sleep quality and cognitive function.
Research completed with healthy men and women between the ages of 21 and 61, showed that CJC-1295 had the ability to increase serum growth hormone levels by 200-1000%. In these individuals, the elevated growth hormone production and release continued for up to 6 days because CJC-1295 has a half life of about 6-8 days. This longer half-life means the body continues to produce beyond the day of injection and is thought to be a great benefit has compared to other peptides that also have similar actions. For this reason and a few more, CJC-1295 has become very effective peptide for safely increasing growth hormone levels.
who is a good candidate for cjc1925 ipamorelin
CJC-1295 can help individuals over the age of 30 to have more energy, a faster metabolism, and stay in better shape as you age. It’s not a hormone itself, so it is a relatively safe and low-risk option when all things are considered. However, it requires a prescription and is delivered via an injection, so there are some important points to cover regarding the CJC 1295 benefits and side effects trade-offs.
Why Combine CJC-1295 and Ipamorelin?
Ipamorelin is a growth-hormone-releasing secretagogue that stimulates the pituitary gland to increase GH production and releases those hormones through the bloodstream to help improve memory, pain, and cognitive skills. CJC-1295 also focuses on the pituitary gland to promote increased growth hormone production, improving muscle mass and function. Together, the two peptides work synergistically to stimulate the pituitary gland into producing a stronger increase in growth hormone. When prescribing CJC-1295 or Ipamorelin peptide therapy, a physician will often combine the two peptides to help increase the benefits of GH treatment. By using a CJC-1295/Ipamorelin blend, patients can double, if not triple, their increased hormone secretion to maximize results.
How CJC-1295/Ipamorelin Works in the Men`s Body?
Both CJC-1295 and Ipamorelin affect the pituitary gland in different ways to stimulate increased GH production. CJC -1295 binds to pituitary receptors to secrete growth hormone-releasing hormone (GHRH) in the brain and stimulate the pituitary gland to increase growth hormone production. On the other hand, Ipamorelin imitates the properties of ghrelin (which is responsible for the breakdown of fats and prevents muscle deterioration) and binds to ghrelin receptors in the brain to stimulate growth hormone production.
However, Ipamorelin is a fast-acting peptide with a half-life of 2 hours, whereas CJC-1295 has a longer half-life of 6-8 days. For that reason, Ipamorelin is typically combined with CJC-1295 for patients to fully utilize the benefits of Ipamorelin therapy and boost increased GH production for an extended duration. Together, the combination provides the instant response of Ipamorelin with the long-lasting effects of CJC-1295, all while amplifying increased growth hormone levels in the blood. In addition, thanks to Ipamorelin’s ability to break down fats, patients have also found the combination of CJC-1295/Ipamorelin very effective for weight loss.
What Is the Dosing for CJC-1295/Ipamorelin?
The most effective method to administer a CJC-1295/Ipamorelin dosage is through subcutaneous injection. The best time to take CJC-1295 is in the evening, as the body usually produces the highest growth hormone levels later in the day. Your physician will determine your prescribed dosage after evaluating your physiology and reviewing your medical history.
In some cases, physicians may also increase the combined dosage of Ipamorelin and CJC-1295 to optimize results. These larger doses are usually most effective when taken before bedtime; however, patients prescribed smaller doses should take their medication at least twice daily. You will need to administer your doses at least one hour before or an hour and a half after eating.
A physician will typically prescribe CJC-1295/Ipamorelin treatment for 12 to 16 weeks; however, that will depend on your medical history and your body’s response to treatment.
Using CJC-1295 Safely
The safest way to use CJC-1295 is via subcutaneous injection through the fatty areas of the skin or the muscle. The most common areas for CJC-1295 injection are usually around the stomach or the upper arm. Since a CJC-1295 injection can stimulate the pituitary gland to dramatically raise GH and IGF-1 levels after long-term use, your physician may recommend periodic breaks from administering CJC-1295 to allow the pituitary gland to recover from overstimulation before continuing treatment. As every person’s physiology is different, your physician may also monitor your progress to determine if and when you will need breaks from using CJC-1295 as a long-term treatment.
How Much Does It Cost To Inject CJC-1295?
Typically, the cost of CJC-1295/Ipamorelin peptide therapy will depend on your dosage level and duration of treatment. After a medical evaluation, your physician will determine the appropriate dosage level to fit your body type and the amount of time you may need to stay on treatment.
There are various ways to help reduce costs for your medication. Your nearest hormone replacement clinic may provide payment options to help make treatment more affordable. You should discuss any payment schedules with their office before starting treatment.
Why combine CJC-1295 & IPAMORELIN?
CJC-1295 and Ipamorelin are typically combined in therapy because the are known to work well together. CJC-1295 takes anywhere from 1-4 hours to reach peak serum in the blood, while Ipamorelin works much quicker. Ipamorelin is cleared from the body more rapidly as it’s half life is about 2 hours. The combination of both peptides ensures a rapid onset with Ipamorelin and lasting effects with CJC-1295. These 2 peptides are incredibly specific at increasing growth hormone levels when compared to other peptides. Other peptide can increase levels of cortisol (as seen with stress, can increase hunger) but neither Ipamorelin nor CJC-1295 have an effect on other hormones which is a great advantage.
How often should you take CJC-1295?
Most prescribers direct that CJC-1295 be taken once daily, via subcutaneous injection (above the muscle, below the skin) in the stomach or abdominal region. Other prescribers recommend a “5 days a week” plan, either with skipping days every 2 or 3 days, or weekdays on, weekends off for injections. There is competing evidence as to the efficacy of these two dosing regimens, but in both cases, the effects of CJC-1295 – higher circulating levels of human growth hormone – tend to last for upwards of a week following administration and continue at that level so long as the administration continues a few times a week.
Does CJC 1295 really work?
The effects of CJC-1295 have been researched thoroughly. It is beneficial in building muscle, losing body fat, and boosting energy levels. It does all these by facilitating the production of more growth hormone for your body.
How long can you take CJC 1295?
Research has shown that administering CJC-1295 once weekly helps to increase plasma GH concentrations (2-10 times more) for a period of up to 6 days after injection. Further, it increases IGF-1 levels by 1.5 to 3 times, for a period of 9 to 11 days, with no adverse side effects.
So Most patients can expect to see slight changes in the body after the first month; however, it can take about 3 to 6 months to fully experience the benefits of CJC-1295/Ipamorelin therapy.
How should CJC-1295/Ipamorelin be used?
CJC-1295/Ipamorelin is injected subcutaneously or under the skin. The injection is taken at night to mimic the natural release cycle of growth hormone.
How Long Can You Take CJC-1295?
You can take CJC-1295 consistently for six months as a long-term treatment. However, when using CJC-1295 with Ipamorelin, there is a risk that it can become no longer effective after long-term use. Therefore, your physician may recommend taking breaks during or after the first six months for your body to avoid becoming resistant to CJC-1295/Ipamorelin medication.
How Often Should You Take CJC-1295?
Your physician will determine how often you take CJC-1295 based on your medical history and physical evaluation. Typically, patients are expected to administer CJC-1295 at least once every day; however, in some cases, physicians may prescribe a plan that allows for a break every few days or on the weekends.
What’s the Difference Between CJC-1295 and CJC-1295 DAC?
Although CJC-1295 and CJC-1295 DAC are quite similar, the most significant difference is the addition of the DAC molecule. Without DAC, the CJC-1295 half-life is reduced by 30 minutes.
How Long Does CJC-1295 Stay in Your System?
Thanks to a longer half-life, CJC-1295 can stay in the human body for a minimum of 6 to 8 days.
Conclusion on CJC 1295 / Ipamorelin peptides:
The effects of CJC-1295 have been researched thoroughly. It is beneficial in building muscle, losing body fat, and boosting energy levels. It does all these by facilitating the production of more growth hormone for your body.
CJC-1295 is a releasing factor for growth hormone and is therefore considered a Prohibited Substance under Section S2 of the WADA Prohibited List. This substance has potential performance-enhancing effects, it is readily available, and there is reason to believe that it is being used within the bodybuilding community.
