Menotropin (also called human menopausal gonadotropin or hMG)，This medication is used to treat certain fertility problems in women. It provides follicle stimulating hormone (FSH) and luteinizing hormone (LH) that help healthy ovaries to make eggs. This medication is usually used in combination with another hormone (human chorionic gonadotropin-hCG) to help you become pregnant by bringing about the growth and release of a mature egg (ovulation).This medication is not recommended for women whose ovaries no longer make eggs properly (primary ovarian failure).
What are menotropins hmg?
Menotropin (also called human menopausal gonadotropin or hMG), Menotropins are a mixture of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are important in the development of follicles (eggs) that are produced by the ovaries in women.
Menotropins are used to help your body produce multiple eggs during ovulation, in preparation for in-vitro fertilization.
HMG is an indication for use in combination with chorionic gonadoopin, is used for primary or secondary amenorrhea caused by insufficient gonadotropin secretion, infertility caused by anovulatory rare menstruation.
How to use HMG Menotropins Solution, Reconstituted (Recon Soln) ?
Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before starting this medication and each time you get a refill. Ask your health care professional how to prepare and use this medication. If you have any questions, ask your doctor or pharmacist.
Inject this medication under the skin as directed by your doctor. The injection is given in the abdomen. The dosage and length of treatment are based on your medical condition, response to treatment and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Use the solution immediately after the medication is mixed. Before using, check this product for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the skin you are going to inject into (the injection site) with rubbing alcohol. Change the injection site each time to lessen injury under the skin. To lessen bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely.
Use this medication exactly as directed by your doctor in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not change the dose or use this drug for a longer period than prescribed unless instructed by your doctor.
What side effects may I notice from receiving this medication?
Headache, mild stomach pain/bloating, redness/pain at the injection site, breast tenderness, or dizziness may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: flu-like symptoms (such as fever, chills, joint pain, muscle ache, tiredness).
Get medical help right away if you have any very serious side effects, including: weakness on one side of the body, trouble speaking, sudden vision changes, sudden severe headache, pain/swelling of the calf muscles, chest pain, shortness of breath.
This medication may cause a condition known as ovarian hyperstimulation syndrome (OHSS). This condition may occur during or after treatment. Rarely, serious OHSS causes fluid to suddenly build up in the stomach, chest, and heart area. Get medical help right away if you develop the following side effects: severe pain or swelling in the lower abdominal (pelvic) area, severe nausea/vomiting, sudden/rapid weight gain, or decreased urination.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Warnings
You should not use this medicine if you have primary ovarian failure, abnormal vaginal bleeding, uncontrolled thyroid or adrenal gland disorders, an ovarian cyst, breast cancer, uterine or ovarian cancer, a tumor of your pituitary gland or hypothalamus, or infertility that is not caused by lack of ovulation.
Do not use menotropins if you are pregnant.
Precautions：Before taking this medicine
Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other products containing follicle stimulating hormone or luteinizing hormone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other fertility problems (such as primary ovarian failure), abnormal uterine/vaginal bleeding, thyroid problems, adrenal gland problems, cancer of the reproductive organs (breast, uterus, ovary), tumor in the brain (such as a pituitary tumor), ovarian cysts/enlarged ovaries (not due to polycystic ovary syndrome), twisting of the ovary (ovarian torsion), personal/family history of blood clots, blood clotting disorders (such as thrombophilia), obesity, stroke, certain heart diseases (such as heart attack), lung problems (such as asthma).
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Multiple births may occur because of this treatment. Consult your doctor for more details.
Stop using this medication when you become pregnant. This medication must not be used during pregnancy. If you think you may be pregnant, tell your doctor right away.
It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
A product that may interact with this drug is: gonadorelin.
Does Menotropins Solution, Reconstituted (Recon Soln) interact with other drugs you are taking?
How should I use menotropins HMG?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
This medicine is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.
Menotropins come in a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Gently swirl the medicine after mixing. Do not shake the mixed medicine or it may foam. Prepare your dose only when you are ready to give an injection, do not save it for later use. Do not use if the mixture has changed colors or has particles in it. Call your pharmacist for new medicine.
You may need to use more than 1 vial of menotropins for your entire dose.
After giving the injection, throw away any portion of the mixed medicine that is not used right away. Do not save it for later use.
For the best results from your fertility treatments, follow your doctor’s instructions very carefully.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
To be sure the medicine is effective, you will need frequent blood tests and ultrasound exams. You may also need to record your temperature on a daily chart.
Store unmixed powder medicine at room temperature away from moisture, heat, and light.
You may also store the powder in a refrigerator. Do not freeze.
Infertility is often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor’s advice.
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, Pleacse go to hospital.
Notes
Do not share this medication with others.
Lab and/or medical tests (such as blood hormone tests such as estradiol level, vaginal ultrasound) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.
Lifestyle changes that may help improve the effect of this medication include limiting alcohol and stopping smoking. Consult your doctor or pharmacist to discuss lifestyle changes that might benefit you.
Missed Dose
It is important to use this medication on a fixed schedule exactly as prescribed by your doctor. If you miss a dose, contact your doctor or pharmacist right away for instructions. Do not double the dose to catch up.
What other drugs will affect menotropins?
Other drugs may interact with menotropins, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
HMG Menotropins dosing information
Usual Adult Dose for Follicle Stimulation:
Assisted reproduction technologies (ART):
Initial dose:
-225 International Units subcutaneously (SC) or intramuscularly (IM) daily.
-Menotropin may be administered together with urofollitropin, and the total combined dose should not exceed 225 international units (150 international units menotropin and 75 international units urofollitropin, or 75 international units menotropin and 150 international units urofollitropin).
Maximum dose:
-450 international units daily
-If given with urofollitropin, the total combined dose of urofollitropin and menotropin should not exceed 450 international units daily.
Duration of therapy: 7 to 20 days
Comments:
-Continue treatment until adequate follicular development is evident, then administer human chorionic gonadotropin (hCG).
-Withhold hCG if monitoring on the last day of therapy suggests an increased risk of ovarian hyperstimulation syndrome (OHSS).
Ovulation induction:
Initial dose: 150 international units SC or IM daily for the first 5 days of treatment.
Maximum dose: 450 international units daily
Duration of therapy: 7 to 12 days
Comments:
-If patient response is appropriate, give hCG 1 day after the last dose of menotropin.
-If inadequate follicle development or ovulation without subsequent pregnancy, treatment may be repeated.
Uses:
-Development of Multiple Follicles and Pregnancy in Ovulatory Women as Part of an Assisted Reproductive Technology (ART) Cycle
-Ovulation induction in patients who have previously received pituitary suppression
Storage
Store in the refrigerator or at room temperature. Protect from light. Do not freeze. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
