Mechano-growth factor (MGF) is an anabolic peptide found in muscle, bone, tendon, neural, and cardiac tissue following periods of increased stress. It is a split variant or isoform of insulin -like growth factor-1 (IGF-1), also known as IGF-1Ec. MGF functions to increase stem cell proliferation in given tissues, allowing for more rapid recovery.
What is MGF (Mechano Growth Factor) and PEG-MGF?
Mechano Growth Factor, or MGF, is a peptide derived from a different sequence of insulin-like growth factor-1 (IGF-1), which plays a large role in childhood development and continues to have anabolic effects throughout adulthood. MGF (Mechano Growth Factor) is released in response to muscles being stretched and exercised. This is particularly abundant when a muscle has been exposed to high-intensity weight training.
MGF has the ability to encourage repair and growth of wasted tissue through the activation of muscle stem cells, thereby increasing the synthesis of proteins necessary for tissue growth. This peptide is ideal for anyone suffering from muscle loss, either due to old age or a particular condition.
PEG-MGF (Pegylated Mechano Growth Factor) is a powerful anabolic peptide that plays a crucial role in muscle repair, growth, and recovery. As a split variant of IGF-1, PEG-MGF is designed to enhance the body’s ability to repair damaged tissues, making it especially beneficial for athletes, bodybuilders, and individuals recovering from injuries. At TRT MD, PEG-MGF is used to accelerate the regeneration of muscle, bone, tendon, and neural tissues, supporting faster recovery after periods of increased stress or injury. Whether you’re looking to improve muscle growth, speed up recovery, or enhance cognitive health, PEG-MGF offers a comprehensive solution for optimizing overall physical performance.
What is the difference between MGF and peg-MGF?
MGF and PEG-MGF all are the splice variant of the IGF gene , but has a different sequence from the IGF-1 produced by the liver, MGF and PEG-MGF increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. Just PEG-MGF is Pegylated Mechano Growth Factor. It is a long-acting variant of MGF, MGF is not PEGylated, the half-life lasts only minutes, Researchers were able to solve this dilemma by pegylating MGF, increasing its half-life of 48- 72 hours. The PEG-MGF extend the half-life of MGF to 2-3 days with few adverse side effects.This is what allowed the peptide to become a viable therapeutic candidate for muscle growth.
MGF And PEG-MGF Benefits
Principle of action of PEG MGF benefits the body
PEG MGF can stimulate the proliferation and differentiation of muscle cells, reduce cholesterol and body fat, enhance immune function, and improve wound healing rates. Let’s learn about how does PEG MGF benefits body through this article.
Mechanical growth factor is a split variant of insulin-like growth factor-1 (IGF-1), a naturally occurring peptide. It is found in muscle, bone, tendon, brain and heart tissue after increased pressure load. MGF works by increasing stem cell proliferation in specific tissues, allowing for faster recovery. Therefore, athletes and bodybuilders use it to recover faster and increase muscle mass, and it is also used for conditions that require increased anabolism.
MGF and PEG are usually used together because the half-life of MGF is very short, only about 6 minutes, and then MGF is pegylated. Adding a PEG group is a safe and effective way to extend the half-life of MGF to 2-3 days with few adverse side effects.
PEG MGF benefits for the body include:
PEG MGF helps improve the connective tissue in muscles, enhances muscle growth and muscle function, promotes nitrogen retention and increases protein synthesis; strengthens bones, joints and tendons, and accelerates recovery after exercise. This is a great recovery product for regular exercisers and an effective way to enhance fitness and performance.
Teeth also benefit from PEG MGF. Studies have shown that PEG MGF improves osteogenic differentiation, factors that may improve the repair of the ligaments that attach teeth to bone, improve tooth stability, and may provide an alternative to tooth extractions and dental implants.
PEG MGF also has potential neuroprotective effects, and studies have explored the long-term effects of elevated MGF levels on the brain and central nervous system. The results suggest that higher levels of MGF help reduce the effects of age-related neuronal degeneration and are therefore neuroprotective.
In summary, PEG MGF is a safe and effective choice for consumers who want to improve their physical fitness, as it can enhance the body’s muscles, bones, nerve levels and functions, helping people become healthy and keep up best performance in their daily lives.
Therefore, its benefits can be summarized as follows：
- Strong anabolic effect and ability to repair and rebuild muscles
- Ability to induce muscle hyperplasia (growth of new muscle cells)
- Neuroprotective effect (protects the nervous system and brain
functions) - Mediates myocardial cell survival and myocardium repairs
- Important roles in tissue growth and wound healing
- Positive role on bone injury healing
Associated Side Effects of MGF AND PEG-MGF
PEG-MGF side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on PEG-MGF. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of PEG-MGF. Despite this, it was listed as a side effect associated with PEG-MGF even though these associated side effects are very uncommon.
Side effects associated with PEG-MGF may include the following:
- Blood pressure drop
- Hypoglycemia (low blood sugar levels)
- Irregular heart rate
- Swelling of the extremities
How MGF works ?
IGF-I is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibers that are required for repair and for the hypertrophy process, which may have similar regulatory mechanisms (Goldspink, G., 2005 p22). MGF is essential for repair and therefore growth of new cells, similar to IGF-1. If MGF is not PEGylated, the half-life is several minutes, therefore, PEGylated MGF must be considered during the compounding process to ensure an appropriate half-life, thereby increasing the duration of action.
Who can benefit from using Mechano-Growth Factor?
Primarily, MGF is used in conditions requiring anabolic enhancement, including bony and soft tissue repair (e.g., tendon, ligament, muscle) following injury, sarcopenia (muscle wasting), stroke, or heart attack. MGF is especially beneficial for individuals requiring enhanced recovery and muscle building following eccentric muscle loading.
Should You Use PEG MGF for Bodybuilding?
PEG-MGF’s main properties in the context of bodybuilding are straightforward:
- Aids muscle repair and growth
- Stimulates muscular hypertrophy via enlargement of muscle fibers
- Promotes proliferation of satellite cells for muscle tissue regeneration
However, PEG-MGF also aids in fat loss by improving the body’s ability to utilize stored fat as an energy source.
This dual mode of action makes PEG-MGF a powerful addition to any bodybuilder’s muscle-building toolbox.
Combined with its ability to significantly speed up the rate of healing from various injuries, it can also help athletes recover faster and stay in the gym without extended breaks.
What is the Point of Taking MGF & PEG Together?
Since MGF has a relatively short half-life (5-7 minutes), MGF is pegylated. Pegylation is the addition of polyethylene glycol (PEG) to the peptide. The addition of the PEG group is a safe and effective way to increase the MGF half-life to 48-72 hours. Conveniently, the PEG group does not bind itself to other substances in the body and is excreted rapidly via urination.
PEG-MGF DOSAGE AND DIRECTIONS FOR USE;
DOSAGE AND DIRECTIONS FOR USE;
Bilateral dosing can be used. Single site administration is also effective. PEG MGF has half-life (several days) and does not need to be consecutively administrated. When injected two-three times per week, it keeps concentration for a long period. The cycle duration is five-six weeks. Administration should take place post workout or on recovery days when you plan on resting.
Reconstituting:
Gently inject 2,5 ml of bacteriostatic water into the vial. Let it sit in refrigerator for 10 – 15 minutes. If there are any undissolved particles left after 15 minutes, gently rotate the vial between your fingers until all of the powder has dissolved and you are left with clear liquid. All our peptides have a purity of at least 98%, most higher than 99%. Peptides are susceptible to heat so our peptides are kept as lyophilised powder in temperature-controlled medical fridges until the time of packaging. Shipments are hand-delivered to the post office at specific times in order to avoid exposure to heat for long periods of time while in the care of postal services. This ensures that the peptide you receive is as pure as possible.
ATTENTION: This compound should be used for research purposes only. All chemical compounds have risks. Please consult your physician and understand the available research before consumption. This product is not intended to diagnose, treat, cure, or prevent any disease.
DRUG INTERACTIONS:
Concomitant glucocorticoid treatment may inhibit the growth promoting effect of of PEG MGF. Pediatric patients with coexisting ACTH deficiency should have their glucocorticoid replacement dose carefully adjusted to avoid an inhibitory effect on growth.
STORAGE INSTRUCTIONS:
Lyophilized PEG MGF is Stable at room Temperature for 90 days, however it is best to store in a freeze below – 8c for any extended period of time.and peptide solution at 4°C. Before mixing, keep between -18 and -20°C. Use within 24 months. Once reconstituted use within 20 days. Do not freeze once reconstituted.
